SMHS is premised on holistic traditional Chinese medical views and systems biology approaches to address health issues. Research carried out in the Institute will involve and integrate data from molecules, cells, as well as studies of both structure and dynamics of interacting nodes, forming networks at multiple levels of a multidimensional matrix, including molecular, cellular, organ, person, family, community, society, and environment. We propose a holistic approach that encourages researchers, healthcare educators, Chinese medicine practitioners, clinicians and healthcare leaders to consider a more systems-based view of the individual (as an environmentally-influenced, complex biological system). When aggregated, such personal information may better explain population diversity (and population medicine), and thereby, help achieve more accurate diagnostic, efficacious therapeutic outcomes for all.
Toward the modernization of Tradition Chinese Medicine
Toward the modernization of Tradition Chinese Medicine
| May 2022 | Director of SMHS, Professor LYU Aiping was elected as a foreign member of The Academy of Europe in the field of System Medicine. |
| November 2022 | The team lead by Director of SMHS, Professor LYU Aiping and PIs, Professor ZHANG Ge, Dr. YU yuanyuan developed a novel aptamer, which has been approved by the U.S. FDA for rare disease drug designation (RPD-2022-667) and orphan drug designation (DRU-2022-9087). |
| April 2023 | PI of SMHS, Dr. Yu Yuanyuan wins Silver Medal at Geneva International Exhibition of Inventions. |
| May 2023 | Collaborator of SMHS, Dr. LYU Haitao, was elected Vice Chairman of Specialty Committee on Drug Metabolism. |
| May 2023 | PI of SMHS, Professor JIA Wei, has been rewarded the President’s Award for Outstanding Performance in Scholarly Work. |
| May 2023 | PI of SMHS, Dr. ZHANG Lu, has been rewarded the President’s Award for Outstanding Performance in Scholarly Work. |
| June 2023 | PI of SMHS, Professor JIA Wei, have been elected as a member of the Academia Europaea. |
| Project Ref. No. | Title | PI | Funding Source(s) |
| T12-201/20-R | Aptamer Molecular Insight & Translational Therapeutics | Prof. LYU Aiping | TRS/RGC |
| 12102722 | Development of combination therapy using a mCRP aptamer and Leflunomide for precision medicine-based rheumatoid arthritis treatment | Prof. LYU Aiping | GRF/RGC |
| 2020B1212030006 | Guandong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research | Prof. LYU Aiping | GDSTC |
| Dysregulated Host - Gut Microbiota Co-Metabolism in Metabolic Associated Fatty Liver Disease | Prof. JIA Wei | RGC | |
| 12100323 | Investigation of abdominal pain management in diarrhea-predominant irritable bowel syndrome via short- chain fatty acids/GLP-1 axis | Prof. BIAN Zhaoxiang | GRF/RGC |
| 12102223 | Macrophagic sclerostin loop2-ApoER2 interaction participates in the suppressive effect of sclerostin on atherosclerosis | Prof. ZHANG Ge | GRF/RGC |
| 12101022 | Impairment of autophagy-lysosomal pathway in Parkinson's disease: Novel roles of HMGB1-TFEB interplay and therapeutic implication of Chinese medicine compounds | Prof. LI Min | GRF/RGC |
| 09203776 | Natural small molecule Isorhamnetin and its optimized derivatives for Parkinson’s disease treatment by targeting TFEB-mediated autophagy | Prof. LI Min | HMRF |
| 12101322 | Key player in the bone-marrow protection of orally-administrated Astragalus polysaccharide RAP after entering Peyer’s patches | Prof. HAN Quanbin Simon | GRF/RGC |
| 12101123 | Radix Astragali polysaccharide RAP: an ideal intestinal M cell-targeted oral vaccine carrier and immunostimulant? | Prof. HAN Quanbin Simon | GRF/RGC |
| 2023A1515011811 | Exploring the mechanism of ARF1/MAP3K-mediated liver fibrosis: Role of adipocyte-derived small extracellular vesicles | Dr KWAN Hiu Yee | Guangdong Province Natural Science Foundation |
| 08193596 | WNT974 and artesunate exhibit synergy in inhibiting colorectal cancer growth by increasing KRAS protein degradation | Dr KWAN Hiu Yee | HMRF |
| 2021Szvup131 | Effect of obesity on the protein profiles in the adipocyte-derived small extracellular vesicles | Dr KWAN Hiu Yee | Shenzhen Virtual University Park Special Fund Project |
| 2021A1515010655 | Exploring the role of hERG/HIF-1 signaling pathway in overweight and obese metastatic CRC patients with resistance to anti-VEGF therapy | Dr KWAN Hiu Yee | Guangdong Province Natural Science Foundation |
| 12102923 | Elucidating the role of TRPM7 chanzyme and its therapeutic potential in neuroinflammation of Alzheimer’s disease | Dr. CHEUNG King Ho | GRF/RGC |
| 12100321 | Unravelling the pathogenic role of lysosomal TPC2 Ca2+ channel in Alzheimer’s disease | Dr. CHEUNG King Ho | GRF/RGC |
| 2023A1515010641 | 中藥小分子線粒體自噬激活劑作為緩解阿爾茨海默症潛在治療藥物的研究 | Dr. CHEUNG King Ho | GDSTC |
| 20212841 | Investigate the therapeutic potential of targeting TRPM7 by carvacrol to mitigate Alzheimer's disease-associated neuroinflammation | Dr. CHEUNG King Ho | HMRF/FHB |
| GHX/133/20S | Computational Models for Health Management System using Multi-Source Data | Dr. ZHANG Lu | TCFS/ITC |
| 2021A1515012226 | A graph-based diploid assembly algorithm for detecting structural variants on linked-read sequencing | Dr. ZHANG Lu | GDNSF |
| 22104123 | Investigating the regulatory role of phenethylamine for serotonin reuptake in the pathogenesis of diarrhea-predominant Irritable Bowel Syndrome | Dr. WONG Hoi Leong Xavier | ECS/RGC |
| Dissecting the Therapeutic Role of 3A2 Antibody for the Treatment of Obesity and Type 2 Diabetes | Dr. WONG Hoi Leong Xavier | ITF/ITC | |
| 22102823 | Blocking exosome release from atrophic skeletal muscle to strengthen bone: a novel therapeutic strategy for muscle atrophy-associated bone loss? | Dr. LIU Jin | ECS/RGC |
| 12102322 | The role of the interactions between N domain and Linker 2 of DKK1 in modulating the immunosuppressive tumor microenvironment mediated by DKK1 C domain | Dr. YU Yuanyuan | GRF/RGC |
| Targeting sclerostin loop3 to promote bone formation with low cardiovascular risk in animal models | Dr. YU Yuanyuan | GRF/RGC | |
| 12201023 | Reducing uncertainties in predictions of future air pollution, heat extremes, and associated health risks in Asia with dynamical downscaling and machine learning | Dr. GAO Meng | GRF |
| 12300823 | Dynamic regulation of p53 signaling and chemoresistance in three-dimensional (3D) cancer models | Prof. SHI Jue | GRF/RGC |
| RFS2021-2S01 | Antitumor dynamics of Natural Killer cell and its response to immune checkpoint inhibitors in 3D tumor organoid models | Prof. SHI Jue | RFS/RGC |
| 12302421 | Dynamic Behaviors and Strategies of Natural Killer Cell Chemotaxis towards Distinct Cancer Targets | Prof. SHI Jue | GRF/RGC |
| 12275229 | Organizational principles of the human microbiome and their applications in fecal microbiota transplantation --- An ecological and functional network-based study | Dr. TIAN Liang | NNSFC |
| C2005-22Y | A novel TCM-based network pharmacology framework to human diseases and drug-disease relationship | Dr. TIAN Liang | RGC |
| 22B2/049A | Construction of a Traditional Chinese Medicine Diagnostic and Treatment Assistance System for Long COVID Based on Big Data and Artificial Intelligence | Dr. TIAN Liang | CMDF |