研究

研究领域

系统医学与健康以整体中医观点和系统生物学方法为基础来解决健康问题。该研究所开展的研究将涉及和整合来自分子、细胞的数据，以及对相互作用节点的结构和动力学的研究，形成多维矩阵的多个层面的网络，包括分子、细胞、器官、人、家庭、社区、社会和环境。我们提出了一种整体方法，鼓励研究人员、医疗保健教育工作者、中医从业者、临床医生和医疗保健领导者考虑以更加系统化的方式看待个人（作为一个受环境影响的复杂生物系统）。汇总后，此类个人信息可以更好地解释人口多样性（和人口医学），从而有助于为所有人实现更准确的诊断和有效的治疗结果。

系统医学

促进中医药现代化的研究

药物发现

促进中医药现代化的研究

成就

May 2022Director of SMHS, Professor LYU Aiping was elected as a foreign member of The Academy of Europe in the field of System Medicine.
November 2022The team lead by Director of SMHS, Professor LYU Aiping and PIs, Professor ZHANG Ge, Dr. YU yuanyuan developed a novel aptamer, which has been approved by the U.S. FDA for rare disease drug designation (RPD-2022-667) and orphan drug designation (DRU-2022-9087).
April 2023PI of SMHS, Dr. Yu Yuanyuan wins Silver Medal at Geneva International Exhibition of Inventions.
May 2023Collaborator of SMHS, Dr. LYU Haitao, was elected Vice Chairman of Specialty Committee on Drug Metabolism.
May 2023PI of SMHS, Professor JIA Wei, has been rewarded the President’s Award for Outstanding Performance in Scholarly Work.
May 2023PI of SMHS, Dr. ZHANG Lu, has been rewarded the President’s Award for Outstanding Performance in Scholarly Work.
June 2023PI of SMHS, Professor JIA Wei, have been elected as a member of the Academia Europaea.

资助信息

Project Ref. No.TitlePIFunding Source(s)
T12-201/20-RAptamer Molecular Insight & Translational TherapeuticsProf. LYU AipingTRS/RGC
12102722Development of combination therapy using a mCRP aptamer and Leflunomide for precision medicine-based rheumatoid arthritis treatmentProf. LYU Aiping

GRF/RGC

2020B1212030006Guandong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease ResearchProf. LYU AipingGDSTC
 Dysregulated Host - Gut Microbiota Co-Metabolism in Metabolic Associated Fatty Liver DiseaseProf. JIA WeiRGC
12100323Investigation of abdominal pain management in diarrhea-predominant irritable bowel syndrome via short- chain fatty acids/GLP-1 axisProf. BIAN ZhaoxiangGRF/RGC
12102223Macrophagic sclerostin loop2-ApoER2 interaction participates in the suppressive effect of sclerostin on atherosclerosisProf. ZHANG GeGRF/RGC
12101022Impairment of autophagy-lysosomal pathway in Parkinson's disease: Novel roles of HMGB1-TFEB interplay and therapeutic implication of Chinese medicine compoundsProf. LI MinGRF/RGC
09203776Natural small molecule Isorhamnetin and its optimized derivatives for Parkinson’s disease treatment by targeting TFEB-mediated autophagyProf. LI MinHMRF
12101322Key player in the bone-marrow protection of orally-administrated Astragalus polysaccharide RAP after entering Peyer’s patchesProf. HAN Quanbin SimonGRF/RGC
12101123Radix Astragali polysaccharide RAP: an ideal intestinal M cell-targeted oral vaccine carrier and immunostimulant?Prof. HAN Quanbin SimonGRF/RGC
2023A1515011811Exploring the mechanism of ARF1/MAP3K-mediated liver fibrosis: Role of adipocyte-derived small extracellular vesiclesDr KWAN Hiu YeeGuangdong Province Natural Science Foundation
08193596WNT974 and artesunate exhibit synergy in inhibiting colorectal cancer growth by increasing KRAS protein degradationDr KWAN Hiu YeeHMRF
2021Szvup131Effect of obesity on the protein profiles in the adipocyte-derived small extracellular vesiclesDr KWAN Hiu YeeShenzhen Virtual University Park Special Fund Project
2021A1515010655Exploring the role of hERG/HIF-1 signaling pathway in overweight and obese metastatic CRC patients with resistance to anti-VEGF therapyDr KWAN Hiu YeeGuangdong Province Natural Science Foundation
12102923Elucidating the role of TRPM7 chanzyme and its therapeutic potential in neuroinflammation of Alzheimer’s diseaseDr. CHEUNG King HoGRF/RGC
12100321Unravelling the pathogenic role of lysosomal TPC2 Ca2+ channel in Alzheimer’s diseaseDr. CHEUNG King HoGRF/RGC
2023A1515010641中藥小分子線粒體自噬激活劑作為緩解阿爾茨海默症潛在治療藥物的研究Dr. CHEUNG King HoGDSTC
20212841Investigate the therapeutic potential of targeting TRPM7 by carvacrol to mitigate Alzheimer's disease-associated neuroinflammationDr. CHEUNG King HoHMRF/FHB
GHX/133/20SComputational Models for Health Management System using Multi-Source DataDr. ZHANG LuTCFS/ITC
2021A1515012226A graph-based diploid assembly algorithm for detecting structural variants on linked-read sequencingDr. ZHANG LuGDNSF
22104123Investigating the regulatory role of phenethylamine for serotonin reuptake in the pathogenesis of diarrhea-predominant Irritable Bowel SyndromeDr. WONG Hoi Leong XavierECS/RGC
 Dissecting the Therapeutic Role of 3A2 Antibody for the Treatment of Obesity and Type 2 DiabetesDr. WONG Hoi Leong XavierITF/ITC
22102823Blocking exosome release from atrophic skeletal muscle to strengthen bone: a novel therapeutic strategy for muscle atrophy-associated bone loss?Dr. LIU JinECS/RGC
12102322The role of the interactions between N domain and Linker 2 of DKK1 in modulating the immunosuppressive tumor microenvironment mediated by DKK1 C domainDr. YU YuanyuanGRF/RGC
 Targeting sclerostin loop3 to promote bone formation with low cardiovascular risk in animal modelsDr. YU YuanyuanGRF/RGC
12201023Reducing uncertainties in predictions of future air pollution, heat extremes, and associated health risks in Asia with dynamical downscaling and machine learningDr. GAO Meng

GRF

12300823Dynamic regulation of p53 signaling and chemoresistance in three-dimensional (3D) cancer modelsProf. SHI JueGRF/RGC
RFS2021-2S01Antitumor dynamics of Natural Killer cell and its response to immune checkpoint inhibitors in 3D tumor organoid modelsProf. SHI JueRFS/RGC
12302421Dynamic Behaviors and Strategies of Natural Killer Cell Chemotaxis towards Distinct Cancer TargetsProf. SHI JueGRF/RGC
12275229Organizational principles of the human microbiome and their applications in fecal microbiota transplantation --- An ecological and functional network-based studyDr. TIAN LiangNNSFC
C2005-22YA novel TCM-based network pharmacology framework to human diseases and drug-disease relationshipDr. TIAN LiangRGC
22B2/049AConstruction of a Traditional Chinese Medicine Diagnostic and Treatment Assistance System for Long COVID Based on Big Data and Artificial IntelligenceDr. TIAN LiangCMDF